Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 34950-82-8, name is 7-Bromo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine, A new synthetic method of this compound is introduced below., Computed Properties of C7H7BrN2O
To a solution of 7-bromo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine (1.50 g, 6.98 mmol) in THF (10.0 mL) was added dropwise NaH (307 mg, 7.67 mmol, 60% purity) at 0C. After addition, the mixture was stirred at 0C for 30 mins, and then CH3I (1.09 g, 7.67 mmol, 478 uL) was added dropwise at 0C. The resulting mixture was stirred at 0C for 30 mins. The reaction mixture was extracted with EtOAc (10.0 mL x 3) and H2O (10.0 mL). The combined organic layers were dried over Na2SO4, filtered and concentrated under reduced pressure to give intermediate (G2.D) (1.78 g, crude) as a yellow solid which was without purfication
The synthetic route of 34950-82-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GenKyoTex Suisse SA; MACHIN, Peter; CHAMBERS, Mark; HODGES, Alastair; SHARPE, Andrew; WISHART, Grant; PERRY, Benjamin; CELANIRE, Sylvain; HEITZ, Freddy; (94 pag.)EP3628669; (2020); A1;,
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