According to the analysis of related databases, 937046-98-5, the application of this compound in the production field has become more and more popular.
Related Products of 937046-98-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 937046-98-5 as follows.
A mixture of 7-bromopyrrolo[2,l-f][l,2,4]triazin-4-amine (670.0 mg, 3.15 mmol), palladium acetate (70.6 mg, 0.31 mmol), l,3-bis(diphenylphosphino)propane (142.7 mg, 0.35 mmol), potassium carbonate (652.0 mg, 4.72 mmol), and 1-butanol (4 mL) in DMF (4 mL) was stirred under carbon monoxide at 80 0C for 4 h. The solid was filtered away and the filtrate was purified by HPLC using a gradient of 25 – 50% of MeCN in water to yield 107.3 mg (15%) of the title compound as a white solid. 1H-NMR (DMSO-J6) delta 8.28 (bs, 1 H), 8.17, (bs, 1 H), 8.05 (s, 1 H), 7.25 (d, J = 4.7 Hz, 1 H), 7.00 (d, J = 4.6 Hz, 1 H), 4.24 (t, 7 = 6.6 Hz, 2 H), 1.694.62 (m, 2 H), 1.45-1.36 (m, 2 H), 0.92 (t, J = 7.3, 3 H); MS [MH-H]+ = 235.2; LCMS RT = 2.73 min.
According to the analysis of related databases, 937046-98-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2007/64931; (2007); A2;,
Bromide – Wikipedia,
bromide – Wiktionary