In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18648-66-3, name is 2-(4-Bromophenyl)-1,1-diphenylethylene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 2-(4-Bromophenyl)-1,1-diphenylethylene
To a reaction vessel purged with nitrogen, 8.11 g of 2- (4-bromophenyl) -1,1-diphenylethylene, 4.24 g of 1,2,3,3a, 4,8b-hexahydrocyclopenta [b] indole, 56 mL of xylene was added, and 0.127 g of triphenylphosphine, 5.43 g of potassium t-butoxide, and 0.27 g of palladium acetate were added, followed by degassing under reduced pressure. The reaction was carried out for 10 hours while stirring at 125 C. Cool to 50 C, add 9.4 g of activated clay,After stirring for 1 hour, suction filtration was performed, 100 mL of water was added, and the mixture was stirred to extract an organic layer. The organic layer was washed with water, separated, dried over sodium sulfate, and concentrated under reduced pressure to obtain an oily crude product. The crude product was purified by column chromatography (carrier: silica gel, eluent: hexane / toluene = 10/1 (volume ratio)) to obtain a yellow solid (9.98 g). 2 g of the obtained yellow solid was brominated according to a conventional method to obtain 2.35 g of a bromo compound represented by the following formula (10).
The synthetic route of 18648-66-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Hodogaya Chemical Industry Co., Ltd.; Okaji, Makoto; (40 pag.)JP2020/15898; (2020); A;,
Bromide – Wikipedia,
bromide – Wiktionary