Synthetic Route of 452-74-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 452-74-4 name is 1-Bromo-2-fluoro-4-methylbenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a stirred solution of 4-bromo-3-fluorotoluene (10 g, 52.9 mmol) in H2SO4 (100 mL) was added [KN03] (5.34 g, 52.9 mmol) at [0C.] After stirring overnight at room temperature, the reaction mixture was poured into ice (200 g) and extracted with EtOAc (3 x 300 mL). The organic solution was washed with brine (200 mL), dried (Na2SO4), and concentrated to give 12.35 g (100%) of title compound as a pale yellow [OIL.’H NMR (CDCIS)] : [300 MHZ No. 8. ]29 (d, [J= 6.] 30 Hz, 1H), 7.12 (d, J= 8.61 Hz, 1H), 2.60 (s, 3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-2-fluoro-4-methylbenzene, and friends who are interested can also refer to it.
Reference:
Patent; WYETH; VIROPHARMA INCORPORATED; WO2003/99824; (2003); A1;,
Bromide – Wikipedia,
bromide – Wiktionary