Electric Literature of 18087-73-5, A common heterocyclic compound, 18087-73-5, name is 3-Bromoimidazo[1,2-b]pyridazine, molecular formula is C6H4BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a 100 ml two port in round bottomed flask, adding 3 – bromo imidazole [1, 2 – b] pyridazine (compound 11) (1g, 5.05mmol), Zn (CF3 SO2 )2 (5.0g,15 . 15mmol), 20 ml CH2 Cl2 , 8 ml H2 O. A system is cooled to 0 C after, slowly dropping t – BuOOH (2.5 ml, 25 . 2mmol) dichloro solution 5 ml. Then completing, maintain 0 C, stirring 3h after, the system moving to room temperature stirring 10h, TLC monitoring reaction process, after completion of the reaction, NaHCO adds by drops full and3 Solution to the system does not produce the bubble as the to. Add dichloromethane extraction, the combined organic phase, anhydrous Na2 SO4 Drying, and the pressure of the coils after silica gel, separation and purification through silica gel column (petroleum ether: ethyl acetate=20:1) to obtain compound 12 (0.13g, yield: 10%), compound 13 (0.40g, yield 30%).
The synthetic route of 18087-73-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Tianjin International Bio-pharmaceutical Joint Institute; Rao Zihe; Bai Cuigai; Chen Yue; Yang Cheng; Wang Lei; Zhong Chuanke; Li Huiying; Sun Tao; Li Jingpei; Wang Yang; (45 pag.)CN106883234; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary