7051-34-5, name is (Bromomethyl)cyclopropane, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C4H7Br
A solution of ethyl 1,3-dithiane-2-carboxylate (10.00 g, 52.00 mmol) and (bromomethyl)cyclopropane (7.02 g, 52.00 mmol) in dry DMF (20 ml_) was added dropwise over a period of 20 min to an ice cooled suspension of NaH (60% oil 15 dispension, 4.20 g, 104.00 mmol) in toluene (60 ml_). The mixture was stirred at rt overnight. Water (50 mL) was added and the mixture was extracted with EtOAc (2 x 50 ml_). The combined organic layers were dried over anhydrous Na2S04, filtered and concentrated to dryness. The residue was purified by column chromatography on silica gel (PE: EtOAc = 5:1) to give the title compound as a yellow oil.
The synthetic route of 7051-34-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PHENEX DISCOVERY VERWALTUNGS-GMBH; STEENECK, Christoph; KINZEL, Olaf; ANDERHUB, Simon; HORNBERGER, Martin; PINTO, Sheena; HERKERT, Barbara; HOFFMANN, Thomas; (129 pag.)WO2019/206800; (2019); A1;,
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bromide – Wiktionary