Adding a certain compound to certain chemical reactions, such as: 337915-79-4, name is 5-Bromo-N1-methylbenzene-1,2-diamine, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 337915-79-4, name: 5-Bromo-N1-methylbenzene-1,2-diamine
Example 45 4- ( (4-Chlorobenzyl) oxy) -1- (l-methyl-2- (trifluoromethyl) -1H- benzimidazol-6-yl) pyridin-2 (1H) -one A) 6-Bromo-l-methyl-2- (trifluoromethyl ) -lH-benzimidazole The mixture of 5-bromo-N1-methylbenzene-l, 2-diamine (300 mg) and TFA (10 ml) was stirred at 90C overnight. The mixture was quenched with saturated NaHC03 solution and extracted with EtOAc. The organic layer was separated, washed with water and brine, dried over MgS04, passed through NH silica gel pad and concentrated in vacuo. The precipitate was collected by filtration, washed with IPE/hexane and dried in vacuo to give the title compound (265 mg) as a purple solid. MS (ESI+) : [M+H] + 280.9.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-N1-methylbenzene-1,2-diamine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; KASAI, Shizuo; IGAWA, Hideyuki; TAKAHASHI, Masashi; MAEKAWA, Tsuyoshi; KAKEGAWA, Keiko; YASUMA, Tsuneo; KINA, Asato; AIDA, Jumpei; KHAMRAI, Uttam; KUNDU, Mrinalkanti; WO2013/105676; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary