Reference of 327-51-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 327-51-5, name is 1,4-Dibromo-2,5-difluorobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
1.. Add 1 mmol of 1,4-dibromo-2,5-difluorobenzene, 2.2 mmol of nitrogen-containing heterocyclic compound and 2.27 mmol of potassium carbonate to 5 mL of dimethyl sulfoxide.Then react at a temperature of 130 C for 6 h,Obtaining a mixed solution I containing a reactant;The mixture I containing the reactant is extracted using a mixture of water and dichloromethane.The organic layer obtained after the extraction is then dried using anhydrous sodium sulfate.The solvent is evaporated under reduced pressure using a rotary evaporator to obtain a crude reaction product I;The crude reaction product I is purified by column chromatography using solvent I as a solvent to obtain 1,4-dicarbazole-2,5-dibromobenzene;The nitrogen-containing heterocyclic compound described in the first step is Carbazole;The solvent I described in the first step is a mixed solution of petroleum ether and dichloromethane, and the volume ratio of petroleum ether to dichloromethane in the solvent I is 5:1;The volume ratio of water to dichloromethane in the mixture of water and dichloromethane described in the first step is 1:5;
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,4-Dibromo-2,5-difluorobenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Heilongjiang University; Xu Hui; Duan Chunbo; Han Chunmiao; Liang Qianqian; (46 pag.)CN107325811; (2019); B;,
Bromide – Wikipedia,
bromide – Wiktionary