Electric Literature of 33070-32-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 33070-32-5, name is 5-Bromo-2,2-difluorobenzodioxole belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A. 1 -(2 ,2-Difluoro-benzor 1,31 dioxol-5 -vD-cyclopropanecarboxylic acid; Step a: 2,2-Difluoro-benzofl ,3] ‘dioxole-5-carboxylic acid methyl ester; A solution of 5-bromo-2,2-difluoro-benzo[l,3]dioxole (11.8 g, 50.0 mmol) and tetrakis(triphenylphosphine)palladium (0) [Pd(PPh3 )4, 5.78 g, 5.00 mmol] in methanol (20 mL) containing acetonitrile (30 mL) and triethylamine (10 mL) was stirred under a carbon monoxide atmosphere (55 PSI) at 75 0C (oil bath temperature) for 15 hours. The cooled reaction mixture was filtered and the filtrate was evaporated to dryness. The residue was purified by silica gel column chromatography to give crude 2,2-difluoro-benzo [1,3] dioxole-5- carboxylic acid methyl ester (11.5 g), which was used directly in the next step.
The synthetic route of 5-Bromo-2,2-difluorobenzodioxole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2008/141119; (2008); A2;,
Bromide – Wikipedia,
bromide – Wiktionary