In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7051-34-5, name is (Bromomethyl)cyclopropane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: (Bromomethyl)cyclopropane
To a stirred solution of 4-fluoro-3-hydroxyhenzonitriie (10.0 g, 78.7 mmoi) in dry DMF (100 mL), KCO3 (21.7 g, 157 mmol) was added followed by addition of cyciopropyimethyl bromide (12,8 g, 94.4 mmoi). The reaction mixture was heated at 90C for 4 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was quenched with cold water and precptated solid was filtered, washed with pentane and dried under vacuum to afford VI Yield: 12.0 g, 94%; 1H NMR (400 MHz, CDCI3) oe 7.2-:,1 1 (m, 3K), 3.90 (d, J= 7.1 Hz, 2H), 1.32-1.29 (m, 1H), 0.76-0.63 (in, 2H), 0.45-0.32 (m, 2H).
The synthetic route of 7051-34-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CV6 THERAPEUTICS (NI) LIMITED; SPYVEE, Mark; SHIRUDE, Pravin S.; (157 pag.)WO2017/6283; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary