Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1559-88-2, name is 3-Bromo-1,2,4,5-tetrafluorobenzene, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 1559-88-2
To a solution of 1-bromo-2,3,5,6-tetrafluorobenzene (CAS No. 1559-88-2) (1 g, 4.37 mmol, 1 equivalent) in THF (20 mL) was added n-butyllithium (2.65 M solution in n-hexane, 1.81 mL, 4.80 mmol, 1.1 equivalents) at -78 C. The reaction mixture was stirred at -78 C. for 30 minutes. To the reaction mixture was added tri-n-butyltin chloride (1.42 mL, 5.24 mmol, 1.2 equivalents). The reaction mixture was allowed to warm up to room temperature over 3 hours. The reaction mixture was concentrated under reduced pressure. To the residue was added water, and the mixture was extracted with DCM. The organic layer was concentrated under reduced pressure, and the residue was purified with silica gel column chromatography (NH silica gel, n-heptane) to afford the title compound (1.49 g). 1H-NMR (400 MHz, CDCl3) delta (ppm): 0.84-0.93 (m, 9H), 1.17-1.39 (m, 12H), 1.46-1.63 (m, 6H), 6.92-7.02 (m, 1H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1559-88-2.
Reference:
Patent; Eisai R&D Management Co., Ltd.; Kurokawa, Toshiki; Yoshida, Yu; Shin, Kogyoku; Kobayashi, Yoshihisa; Fukumoto, Hironori; Takeda, Kunitoshi; Ohashi, Yoshiaki; Kotake, Makoto; Shibuguchi, Tomoyuki; Watanabe, Toru; Kita, Yoichi; Hirota, Shinsuke; Fukuyama, Takashi; Kamada, Yasuaki; (59 pag.)US2017/137436; (2017); A1;,
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bromide – Wiktionary