Adding a certain compound to certain chemical reactions, such as: 328-70-1, name is 1-Bromo-3,5-bis(trifluoromethyl)benzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 328-70-1, Application In Synthesis of 1-Bromo-3,5-bis(trifluoromethyl)benzene
A 250 ml round-bottom flask was charged with magnesium (turnings; 2.18 g; 89.5 mmol), and argonated. Then, Et2O (60 ml), I2 (one crystal) were added, and a solution of 1-bromo-3,5-bis(trifluoromethyl)benzene (26.67 g; 91.0 mmol) in Et2O (60 ml) was added portionwise over 45 min with stirring. After 2 h the mixture was cooled with ice-water bath and AsCl3 (2.2ml; 26.1 mmol) was added dropwise, that caused formation of crystalline precipitate. Stirring was continued at RT for 16 h, and aqueous NH4Cl (100 ml; 10%) was added. The resulted mixture was extracted with ethyl acetate (3 100 ml), and combined organic phases were washed with brine (100 ml), and dried over MgSO4. The mixture was filtered, evaporated, and residue grey-brownish solid was crystallized from n-hexane (dissolved in boiling solvent and slowly cooled to ca. 0 C; 30 ml) to obtain 8d (17.99 g; 25.18 mmol; 97%) as white solid.
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Reference:
Article; Grudzie?, Krzysztof; Basak, Tymoteusz; Barbasiewicz, Micha?; Wojciechowski, Tomasz M.; Fedory?ski, Micha?; Journal of Fluorine Chemistry; vol. 197; (2017); p. 106 – 110;,
Bromide – Wikipedia,
bromide – Wiktionary