Electric Literature of 1435-52-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1435-52-5 as follows.
In an oven-dried 100 mL round bottom flask boronic acid 3(1.00 g, 1.0 eq.) was added, followed by dibromobenzene 2 (3.60 g, 2.0 eq) and palladium reagent (150 mg) were dissolved in dioxane to give a yellow solution. Sodium bicarbonate aqueous solution (2 M, 14 mL) was added causing a beige suspension to form. The suspension was heated at 80 0C for 20 h. The reaction was evaporated to dryness and the residue partitioned between EtOAc (75 mL) and water (25 mL). The layers were separated and the organic layer washed with brine, dried over magnesium sulfate, filtered and
According to the analysis of related databases, 1435-52-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; INFINITY DISCOVERY, INC.; WO2008/63300; (2008); A2;,
Bromide – Wikipedia,
bromide – Wiktionary