In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 61921-39-9 as follows. Quality Control of 4-Bromotetraphene
52 ml (130 mmol) of n-butyllithium (2.5 M in n-hexane) are added dropwise with vigorous stirring to a suspension of 30.7 g (100 mmol) of 4-bromo-benz[a]anthracene (I) in 1000 ml of THF at -78 C., and the mixture is stirred for a further 2 h. 16.7 ml (150 mmol) of trimethyl borate are added in one portion to the red solution with vigorous stirring, the mixture is stirred at -78 C. for a further 30 min., then warmed to room temperature over the course of 3 h, 300 ml of water are added, and the mixture is stirred for 30 min. The organic phase is separated off and evaporated to dryness in vacuo. The solid is taken up in 100 ml of n-hexane, filtered off with suction, washed once with 100 ml of n-hexane and dried in vacuo. Yield: 23.7 g (87.0 mmol), 87.0%, purity about 90.0% (NMR) of boronic acid, with varying amounts of boronic anhydride and borinic acid. The boronic acid can be used in this form without further purification.
According to the analysis of related databases, 61921-39-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Merck Patent GmbH; Anemian, Remi Manouk; Ludemann, Aurelie; Eberle, Thomas; Hoeger, Sigurd; Reis, Eva Maria; Bobbe, Vanessa; US8906893; (2014); B2;,
Bromide – Wikipedia,
bromide – Wiktionary