In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 937046-98-5, name is 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 937046-98-5
Intermediate 69A 7-( Prop- 1 -en-2-yl)pyrrolo[2, l-fj[l ,2,4]triazin-4-amine The starting material 7-bromopyrrolo[2, 1 -fj [ 1 ,2,4]triazin-4-amine was synthesized according to the procedure described in WO 2007/056170-A2 (Intermediate B). Under an argon atmosphere, 7-bromopyrrolo[2, 1 -f] [ 1 ,2,4]triazin-4-amine (426 mg, 2 mmol) and 4,4,5, 5-tetramethyl-2-(prop-l -en-2-yl)-l,3,2-dioxaborolane (420 mg, 2.5 mmol) were dissolved in a mixture of 1 ,2-dimethoxyethane (10 mL) and aqueous sodium carbonate solution (2 M, 4 mL). The reaction mixture was degassed, and 1 , 1 ‘-bis(diphenylphosphino)ferrocenepalladium(II) chloride (73 mg, 0.1 mmol) was added. After stirring at 90C overnight, the reaction mixture was diluted with ethyl acetate (40 mL), water (10 mL) was added, and the layers were separated. The aqueous layer was extracted with ethyl acetate (2 x 40 mL), and the combined organic layers were dried over sodium sulfate, filtered and concentrated. The residue was purified by flash chromatography (puriFlash, Interchim, cyclohexane/ethyl acetate 1 : 1 to 100% ethyl acetate gradient) to yield the title product as a slightly yellow solid. Yield: 304 mg (81 % of th.). HPLC (method 10): R, = 0.83 min; LC-MS (method 10): RT = 0.57 min; MS (ESIpos): m/z (%) = 1 75. 1 (100) [M+H]+. ? Iota NMR (400 MHz, 4J-DMSO): delta (ppm) = 2.15 (s, 3H), 5.22 (m, 1H), 6.30 (m, H I ). 6.73 (d, 1H), 6.91 (d, 1H), 7.69 (m, 1H), 7.91 (s, 1H).
The synthetic route of 937046-98-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER INTELLECTUAL PROPERTY GMBH; Bayer Pharma Aktiengesellschaft; KLAR, Juergen; VOEHRINGER, Verena; TELSER, Joachim; LOBELL, Mario; SUessMEIER, Frank; LI, Volkhart Min-Jian; BOeTTGER, Michael; GOLZ, Stefan; LANG, Dieter; SCHLEMMER, Karl-Heinz; SCHLANGE, Thomas; SCHALL, Andreas; FU, Wenlang; WO2013/4551; (2013); A1;,
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