Synthetic Route of 1137142-58-5,Some common heterocyclic compound, 1137142-58-5, name is 2-Bromoimidazo[2,1-b][1,3,4]thiadiazole, molecular formula is C4H2BrN3S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Intermediate 19; 2-(4-Fluoro-phenoxy)-imidazo[2,1-b][1,3,4]thiadiazole; A mixture of 2-bromo-imidazo[2,1-b][1,3,4]thiadiazole (1.0 g, 4.90 mmol) and 4- fluorophenol (2.2 g, 19.60 mmol) was heated under microwave irradiation at 135C for 3.5 hours. On cooling, the mixture was diluted with dichloromethane (7 mL), adsorbed in silica and purified by column chromatography (Biotage/Flash, silica, methanol:dichloromethane 0.2:9.8 to 2:8) to give 2-(4-fluoro-phenoxy)- imidazo[2,1-b][1 ,3,4]thiadiazole as a white solid (610 mg, 53% yield).1H-NMR (300 MHz, CDCI3): delta 7.54 (d, J = 1.3 Hz, 1 H), 7.29 (m, 2H), 7.21 (d, J =1.2 Hz, 1 H), 7.14 (m, 2H).MS (ES+) m/z 236 (M+H)+ (MW: 235.24).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Bromoimidazo[2,1-b][1,3,4]thiadiazole, its application will become more common.
Reference:
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); WO2009/40552; (2009); A2;,
Bromide – Wikipedia,
bromide – Wiktionary