Related Products of 1074-24-4,Some common heterocyclic compound, 1074-24-4, name is 1,4-Dibromo-2,5-dimethylbenzene, molecular formula is C8H8Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1,4-dibromo-2,5-dimethylbenzene: 1H-1,2,4- triazole: potassium carbonate: copper oxide molar ratio is 2: 10: 30: 1. To a 50mL three-neck round bottom flask equipped with a magnetic stirrer, reflux condenser and thermometer was added CuO (0.0398mg,0.5mmol), potassium carbonate (2.0731g, 15mmol), 1H-1,2,4-triazole (0.345mg, 5mmol), 1,4- dibromo-2,5-dimethylbenzene (0.3360g, 1mmol ), 20mL DMF. Stirring at 100 deg.C. React for 24 hours. After completion of the reaction, the reaction solution was cooled to room temperature, filtered and the filtrate was added 100mL of water, heavy precipitate precipitation, filtration, filter cake was collected, yield 60percent.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,4-Dibromo-2,5-dimethylbenzene, its application will become more common.
Reference:
Patent; Tianjin Normal University; Wang, Ying; (11 pag.)CN105669720; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary