Adding a certain compound to certain chemical reactions, such as: 10485-09-3, name is 2-Bromoindene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10485-09-3, SDS of cas: 10485-09-3
A mixture of 50.0 ml (20.0 mmol) of 0.4 M mesitylmagnesium bromide in THF, 230 mg (0.40 mmol) of Pd(dba)2, 162 mg (0.80 mmol) of P^Bu3, and 3.90 g (20.0 mmol) of 2-bromo-lH-indene was stirred for 48 h at ambient temperature. Then, to the resulting mixture 200 ml of brine was added. The organic layer was separated, and the aqueous layer was extracted with 3 x 100 ml of ether. The combined organic fractions were dried over K2CO3 and then evaporated to dryness. The product was isolated by flash chromatography on Silica Gel 60 (40-63 urn, d 30 mm, 1 300 mm, eluent: hexanes-dichloromethane, 20:1, vol.). Yield 3.19 g (68%) of white solid.Anal. calc. for C18H18: C, 92.26; H, 7.74. Found: C, 92.33; H, 7.73.1H NMR (CDCl3): delta 7.52 (m, IH, 7-H in indenyl), 7.46 (m, IH, 4-H in indenyl), 7.35 (m, IH, 6-H in indenyl), 7.24 (m, IH, 5-H in indenyl), 6.97 (s, 2H, 3,5-H in mesityl), 6.68 (m, IH, 3-H in indenyl), 3.60 (m, 2H, CH2), 2.36 (s, 3H, 4- Me in mesityl), 2.22 (s, 6H, 2,6-Me in mesityl).
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Reference:
Patent; EXXONMOBIL CHEMICAL PATENTS INC.; WO2007/70038; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary