Related Products of 4549-33-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4549-33-1 as follows.
General procedure: Furanchalcone or quinoline (1 mmol), potassium hydroxide(1.5 mmol, 84.2 mg) and acetonitrile (10 mL), were placedin a 25 mL flat-bottomed flask equipped with a magneticstirring bar. The mixture was stirred and heated to reflux fora period of 5 min, under microwave irradiation. Then, 1,omega-dibromoalkane (1.1 mmol) was added to the reaction mixture,which was refluxed for 30 min (200 W). The crudereaction mixture was concentrated on a rotatory evaporatorand the residue was purified by column chromatographyover silica gel eluting with hexane and a mixture of hexaneethylacetate (9:1 ratio) to obtain bromoalkyl derivatives inyields ranging between 61 and 76%. Monitoring of thereaction progress and product purification was carried outby TLC.
According to the analysis of related databases, 4549-33-1, the application of this compound in the production field has become more and more popular.
Reference:
Article; Garcia, Elisa; Coa, Juan C.; Otero, Elver; Carda, Miguel; Velez, Ivan D.; Robledo, Sara M.; Cardona, Wilson I.; Medicinal Chemistry Research; vol. 27; 2; (2018); p. 497 – 511;,
Bromide – Wikipedia,
bromide – Wiktionary