Share a compound : 2695-48-9

Synthetic Route of 2695-48-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2695-48-9 as follows.

To a stirred suspension of sodium hydride (840mg of a 60% dispersion in oil, 21.0mmol) in N,N- dimethylformamide (40ml) was added in one portion di-fe/t-butyl iminodicarbamate (4.56g, 21.0mmol). After stirring for 40mins, 8-bromooct-1-ene (3.50ml, 21mmol) was added and mixture was stirred at room temperature overnight. The solvent was removed in vacuo and the residue dissolved in water and ethyl acetate. The organic layer was separated and washed with water then brine, dried (magnesium sulphate) and the solvent removed in vacuo. The residue was purified by column chromatography on silica gel eluting with diethyl ethe?pentane (1/99 to 6/94 by volume) to furnish the title compound as a clear oil, 5.51 g.

According to the analysis of related databases, 2695-48-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PFIZER LIMITED; WO2007/107828; (2007); A2;,
Bromide – Wikipedia,
bromide – Wiktionary