Adding a certain compound to certain chemical reactions, such as: 52997-43-0, name is 7-(Bromomethyl)pentadecane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52997-43-0, Formula: C16H33Br
The aqueous NaOH solution (13.5 ml, 6 M) was placed in a reaction flask,Ventilation (nitrogen) three times,A solution of p-bromophenethyl mercaptan (9.77 g, 45 mmol) was added dropwise under nitrogen,After dripping,The phase transfer catalyst was added tetrabutylammonium iodide (catalyst amount, 1.99 g).Ten minutes later, 61 ml of tetrahydrofuran was added,To be uniform,Ethyl 2-hexyl decane (16.50 g, 54 mmol) was added dropwise over 10 min.The temperature was then raised to 45 C,The reaction was stirred overnight under vigorous stirring.Reaction is completed,The reaction solution was poured into dilute hydrochloric acid (1 M)Extracted with dichloromethane,Dried over anhydrous sodium sulfate,The solvent was distilled off under reduced pressure,The column was crystallized from 16.3 g of a colorless transparent liquid in 85% yield.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 7-(Bromomethyl)pentadecane, and friends who are interested can also refer to it.
Reference:
Patent; Beijing Institute of Printing; Wang, Wenguang; Yang, Mingcong; Pu, Jialing; (29 pag.)CN104961665; (2017); B;,
Bromide – Wikipedia,
bromide – Wiktionary