Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 656-64-4, name is 3-Bromo-4-fluoroaniline, A new synthetic method of this compound is introduced below., Formula: C6H5BrFN
4-Amino-N-hydroxy-1,2,5-oxadiazol-3-methylimidoyl chloride (36.78 g, 0.23 mol, 1.0 eq)Dissolved in water (318 ml), stirred at 60 C, and added 3-bromo-4-fluoroaniline (47.50 g, 0.25 mol, 1.1 eq).Stir at 60 C for about 10 min,NaHCO3 (29.40 g, 0.35 mmol, 1.5 eq) in water (318 mL) was added dropwiseThe solution was added dropwise after 20 minutes, and the mixture was stirred at 60 C for 30 min, cooled to room temperature, and the reaction solution was suction filtered.The filter cake was washed with water, the filter cake was drained, beaten with water overnight, and filtered by suction the next day to obtain a gray solid, which was dried.The objective product was obtained (61.21 g, yield: 84.2%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Nanjing Yaojie Good Health Biological Technology Co., Ltd.; Wu Yongqian; Li Lin; (48 pag.)CN108727361; (2018); A;,
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bromide – Wiktionary