1073-39-8, name is 3-Bromobicyclo[4.2.0]octa-1,3,5-triene, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 3-Bromobicyclo[4.2.0]octa-1,3,5-triene
To a mixture of 3-bromobicyclo[4.2.0]octa-1,3,5-triene (309.3 mg, 1.69 mmol, 1.20 equiv) in tetrahydrofuran (12 mL) was added n-BuLi (0.68 mL, 1.20 equiv, 2.5 M in hexane) dropwise at -78C. The solution was stirred for 30 min at -78C. To the resulting mixture was then added a solution of 5-bromo-2- ethylbenzaldehyde (300 mg, 1.41 mmol, 1.00 equiv) in tetrahydrofuran (3 mL) dropwise at -78C. The reaction mixture was stirred for 2 h at -78C. NH4CI/H20 was added and the mixture was extracted with ethyl acetate three times. The combined extracts were washed with brine and dried over Na2S04, then concentrated and purified by chromatography on silica gel (1 :5 EA/PE) to yield bicyclo[4.2.0]octa-1 (6),2,4-trien-3-yl(5-bromo-2-ethylphenyl)methanol as a yellow oil. MS (ES) m/z: 299.0, 301.0[M-OH]+.
The synthetic route of 1073-39-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; GAUL, Micheal; KUO, Gee-Hong; XU, Guozhang; LIANG, Yin; (218 pag.)WO2018/89449; (2018); A1;,
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