Application of 656-64-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 656-64-4, name is 3-Bromo-4-fluoroaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
4-Amino-N-hydroxy-1,2,5-oxadiazole-3-carboximidoyl chloride 3(3.24 g, 20 mmol) was mixed with water (70 mL) and 3-bromo-4-fluoroaniline (4.18 g, 22 mol, 1.1 equiv). At 60 C, a solution of sodiumbicarbonate (3.36 g, 40 mmol, 2 equiv) in water (15 mL) was added tothe mixture by drops then resulting mixture was heated to reflux. Afterpurification, compound 4 was obtained as a white solid (5.75 g, 91%).1H NMR (300 MHz, DMSO-d6): delta=11.46 (s, 1H), 8.89 (s, 1H), 6.99 (t,J=8.8 Hz, 1H), 6.81 (dd, J1=6.0 Hz, J2=2.7 Hz, 1H), 6.56-6.51 (m,1H), 6.28 (s, 2H) ppm.
The synthetic route of 3-Bromo-4-fluoroaniline has been constantly updated, and we look forward to future research findings.
Reference:
Article; Feng, Xi; Shen, Pei; Wang; Li; Bian, Jinlei; Biochemical Pharmacology; vol. 168; (2019); p. 214 – 223;,
Bromide – Wikipedia,
bromide – Wiktionary