Application of 314084-61-2, A common heterocyclic compound, 314084-61-2, name is 2-Bromo-1,3-diethyl-5-methylbenzene, molecular formula is C11H15Br, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Dihydro-1H-pyrazolo[1,2-d][1,4,5]oxadiazepine-7,9(2H,8H)-dione (3.4 g, 20 mmol) at 20 C Soluble in 40mL dimethylformamide,And added 2,6-diethyl-4-methylbromobenzene (4.09 g, 18 mmol) andPd(PPh3)2Cl2 (1.26 g, 1.8 mmol) was then stirred at 135 C for 6 hours. After cooling the above reaction system to room temperature, 200 mL of ethyl acetate and 200 mL of diethyl ether were added, and the reaction mixture was poured into a suction filter.100 mL of water and 100 mL of dichloromethane were added to the filtered residue.Acidified with hydrochloric acid. The organic phase was separated, dried and concentrated by evaporation.The residue was chromatographed on silica gel column (ethyl acetate / petroleum ether = 2:1 (V/V))8-(2,6-Diethyl-4-methylphenyl)tetrahydropyrazolo[1,2-d][1,4,5]oxazepine-7,9(2H,8H) -dione4.72 g, yield 82.9%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Lanzhou Fine Chemical High Technology Development Corporation; Gansu Chemical Institute Co., Ltd.; Liu Rong; Wang Xiaoxia; Ji Pengyan; Wei Wanlei; He Kaiyu; Liu Yunli; (9 pag.)CN108864144; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary