Synthetic Route of 7051-34-5,Some common heterocyclic compound, 7051-34-5, name is (Bromomethyl)cyclopropane, molecular formula is C4H7Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of methyl 3-hydroxy-4-methoxybenzoate (5 g, 27.47 mmol) in DMF (30 mL) were added anhydrous potassium carbonate (7.58 g, 54.95 mmol) and (bromomethyl) cyclopropane (3.8 mL, 41.20 mmol) in turn. The mixture was stirrred in a sealing tube at 60 for 4.5 h. The reaction mixture was diluted with saturated aqueous NaCl solution (20 mL) . The resulting mixture was extracted with EtOAc (25 mL × 3) . The combined organic layers were washed with water (30 mL × 3) , dried over anhydrous Na2SO4 for 1 h and concentrated to give the title compound as a white solid (6.26 g, 96.5) 1H NMR (400 MHz, CDCl3) : delta ppm 7.66 (d, J 8.4 Hz, 1H) , 7.52 (s, 1H) , 6.87 (d, J 8.4 Hz, 1H) , 3.92 (s, 3H) , 3.89 (d, J 7.0 Hz, 2H) , 3.87 (s, 3H) , 1.32-1.36 (m, 1H) , 0.62-0.67 (m, 2H) , 0.34-0.38 (m, 2H) and MS-ESI: m/z 237.1 [M+H] +.
The synthetic route of 7051-34-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; LIU, Bing; YU, Tianzhu; ZHANG, Xiangyu; ZHANG, Shiguo; ZHANG, Jiancun; CHENG, Changchung; (426 pag.)WO2016/34134; (2016); A1;,
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