Application of 626-88-0,Some common heterocyclic compound, 626-88-0, name is 1-Bromo-4-methylpentane, molecular formula is C6H13Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A solution of secondary amine (0.55 mmol), the appropriate alkyl bromide (0.36-0.46 mmol) and triethylamine (0.55 mmol) in N,N-dimethylformamide (3 mL) was stirred for 18 h at room temperature. The solvent was evaporated under reduced pressure and concentrated sodium carbonate solution (30 mL) was added to the crude residue. The aqueous solution was extracted with CH2Cl2 (3?30 mL), the combined organic layers were dried over MgSO4 and evaporated. The crude material was purified by flash column chromatography (CH2Cl2:CH3OH, 9:1 and 1% NEt3).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-4-methylpentane, its application will become more common.
Reference:
Article; Keller, Marco; Wolfgardt, Annette; Mueller, Christoph; Wilcken, Rainer; Boeckler, Frank M.; Oliaro-Bosso, Simonetta; Ferrante, Terenzio; Balliano, Gianni; Bracher, Franz; European Journal of Medicinal Chemistry; vol. 109; (2016); p. 13 – 22;,
Bromide – Wikipedia,
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