Electric Literature of 117635-21-9,Some common heterocyclic compound, 117635-21-9, name is 1,4-Dibromo-2,5-dihexylbenzene, molecular formula is C18H28Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 3: In the dry box the mixture of boronic acid pinacol ester,3, (5.8g.16.B2mmol), 1,4-dlbmmo-295-dthexylbenzene(3.4g, 8.4mmol), .Aiiquat 336(0.Bg), and Pd(PP%)4 (0.486g, 0421 mmol) in degassed toluene (lOOmL) was prepared. Outside dry box, the degassed Na2003 (2.87g, 2523mmo1 In 50 mL of water) solution was added to the fomier mixture under nitrogen, and then the resultant mixture was stirred at 90C for 42hrs. Theorganic layer was separated and the aqueous layer was extracted with ethyl acetate. The combined orgqnlc layers were dried over anhydrous MgSO4. Filtration, concentration & the filtrate, and then the silica column chromatography (0-3% ethyl acetae in hexane) provided the desired product (2Mg, 8% yield) as a viscous liquid
The synthetic route of 117635-21-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; RADU, Nora Sabina; FENNIMORE, Adam; WO2015/89027; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary