Application of 452-74-4, A common heterocyclic compound, 452-74-4, name is 1-Bromo-2-fluoro-4-methylbenzene, molecular formula is C7H6BrF, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3-Fluoro-4-bromotoluene (5.0 g, 27 mmol) in carbon tetrachioride (50 mE) was treated with N-bromosuccinimide (7.0 g, 40 mmol, 1.5 eq) and heated to 80 C. Henzoyl peroxide (65 mg, 0.27 mmol, 0.01 eq.) was added and heating was continued for 1 h. The reaction was then cooled to ambient temperature and filtered, and the filtercake was washed sparingly with chloroform. The filtrate was washed with water and brine, dried over Na2SO4, and concentrated to give crude 3-fluoro-4-bromobenzyl bromide as a clear oil which was used without thrther purification.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; INFINITY PHARMACEUTICALS, INC.; BEHNKE, Mark L.; CASTRO, Alfredo C.; EVANS, Catherine A.; GRENIER, Louis; GROGAN, Michael J.; LIU, Tao; SNYDER, Daniel A.; TIBBITTS, Thomas T.; US2015/368278; (2015); A1;,
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