Synthetic Route of 955959-84-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 955959-84-9 as follows.
In a round bottom flask, 4.9 g of aniline, 30 g of starting material X1, t-BuONa 14.5 g, Pd2(dba)3 2.2 g, and (t-Bu)3P 2.3 m were dissolved in 200 ml of toluene, stirred at reflux. The reaction was confirmed by thin layer chromatography (TLC), and after adding water, the reaction was terminated. Use methyl cellulose (MC) to extract organic layers and reduce themAfter pressure filtration, column purification and recrystallization were carried out to obtain 16.2 g (yield 81percent) of IA-1.
According to the analysis of related databases, 955959-84-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Dongjin Shimeiken Co., Ltd.; Jin Jintai; Xian Haowan; Jin Dongjun; Lin Donghuan; Li Yingzhen; Lin Dazhe; Han Zhengyou; Pei Weizhen; Jin Yingsen; Li Dongxuan; (49 pag.)CN108689913; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary