Related Products of 553-94-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 553-94-6, name is 2,5-Dimethylbromobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
In a 250mL dry four-neck flask, evacuate and replace the system three times with nitrogen, and then add 60mL of anhydrous ether, 3.77g of magnesium filings (molecular weight 24.3, 155.20mmol, 1.2eq) and a small iodine (15mg) under nitrogen protection. ), Raise the temperature to 60 C, and slowly add about one-fifth of a solution of 2,5-dimethylbromobenzyl ether [25.75g of 2,5-dimethylbromobenzyl (molecular weight 199.09, 129.33mmol) , 1eq) dissolved in 30mL of ether], the temperature did not increase significantly, stirred at this temperature for about 30 minutes, at this time observed the temperature rose significantly, reached a reflux state, at the same time the yellow in the solution faded and turned off-white. The remaining 2,5-dimethylbromobenzyl ether solution was slowly added dropwise, and the drop was completed in about 40 minutes. After dripping and holding for 1 hour, it was observed that the magnesium dust in the reaction solution had basically disappeared. The temperature of the reaction solution was lowered to 0 C, and 46.04 g of ethylene oxide (molecular weight 44.05, 1034.6 mmol, 8.0 eq) was slowly added. After the addition, the temperature was maintained at about 0 C and stirring was continued for 3 hours. 70 mL of saturated ammonium chloride solution was added to extract the reaction. After the tetrahydrofuran was distilled off under negative pressure, the aqueous phase was extracted three times with 40 mL of dichloromethane. The dichloromethane phases were combined and the dichloromethane was evaporated to dryness under negative pressure to obtain 18.87 g (molecular weight 150.22, theoretically obtained). 19.43 g) a white solid. The purity was 97.5%, which was 2,5-dimethylphenylethanol, and the mass yield was 94.69%.
The synthetic route of 2,5-Dimethylbromobenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Jiangsu Zhongqi Technology Co., Ltd.; Wu Yaojun; Bu Long; Zhang Pu; Hou Yuanchang; (7 pag.)CN110357774; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary