Some tips on 1-Bromo-4-fluoro-2,3-dimethylbenzene

The synthetic route of 52548-00-2 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 52548-00-2, name is 1-Bromo-4-fluoro-2,3-dimethylbenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C8H8BrF

Step a. To a solution of 3-bromo-6-fluoro-o-xylene (CAS Number 52548-00-2; 3.00 g, 14.8 mmol) in CC1 (45 ml) was added NBS (5.780 g, 32.51 mmol) at rt. The reaction mixture was exposed to a UV light source which increased the temperature, in this manner the reaction mixture was heated at 85C for 2 h. The reaction mixture was cooled to rt and poured into saturated NaHC03 solution (100 ml). The resulting mixture was extracted with EtOAc (3 x 100 ml). The combined organic phase was washed with brine (100 ml), dried over Na2S04, filtered and concentrated under reduced pressure yielding 1-bromo-2,3-bis(bromomethyl)-4-fluorobenzene (5.80 g, 16.25 mmol). This material was directly used for next step without any further purification. LCMS: Method A, 2.489 min.

The synthetic route of 52548-00-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MISSION THERAPEUTICS LIMITED; GIBSON, Karl Richard; JONES, Alison; KEMP, Mark Ian; MADIN, Andrew; STOCKLEY, Martin Lee; WHITLOCK, Gavin Alistair; WOODROW, Michael D; (241 pag.)WO2017/158388; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary