Synthetic Route of 393-37-3, A common heterocyclic compound, 393-37-3, name is 5-Bromo-2-fluorobenzotrifluoride, molecular formula is C7H3BrF4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 4-bromo- 1 -fluoro-2-(trifluorom ethyl )benzene (5.0 g, 20.5 mmol, 2.9 mL) in THF (50.0 mL) was added LDA (2 M, 13.3 mL) at -78C. The mixture was stirred at – 78C for 1 hr. Then DMF (1.8 g, 24.6 mmol, 1.9 mL) was added and stirred for 1 h at -78C. The mixture was poured into Sat H4CI (20.0 mL) and extracted with ethyl acetate (20.0 mL chi 3). The combined organic layers were washed with brine (20.0 mL chi 3), dried over Na2S04, filtered and concentrated under reduced pressure to give a residue. The residue was purified by column chromatography (S1O2) to afford 5-bromo-2-fluoro-3-(trifluoromethyl)benzaldehyde (4 g, 14.7 mmol, 71.7% yield). MR (CHLOROFORM-c , 400 MHz): delta 10.35 (s, 1H), 8.19 (dd, 7= 2.5, 5.4 Hz, 1H), 7.98 (dd, 7= 2.1, 6.1 Hz, 1H)
The synthetic route of 393-37-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; QUENTIS THERAPEUTICS, INC.; VACCA, Joseph P.; LI, Dansu; BETTIGOLE, Sarah; (214 pag.)WO2019/94641; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary