Adding a certain compound to certain chemical reactions, such as: 5433-01-2, name is 1-Bromo-3-isopropylbenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5433-01-2, Product Details of 5433-01-2
A. (E)-3-(3-lsorhoropyl-phenyl)-propenal; 1-Btauomo-3-isopropylbenzene (14.5 g, 69 mmol), acrolein-diethylacetal (33.5 mL, 208 mmol), Bu4NOAc (44 g, 138 mmol), K2CO3 (14.5 g, 104 mmol), KCI (5.2 g, 70 mmol) and Pd(OAc)2 (0.5 g, 2 mmol) are suspended in 290 mL DMF and heated for 24 h at 900C. The reaction mixture is cooled to ambient temperature, diluted with water (10OmL) and acidified with 2N HCI. After extraction with TBME, the organic layer is washed with water, dried over Na2SO4, filtered and concentrated. The crude product is purified by flash chromatography on silica gel (eluent: hexane/AcOEt 19/1) to give the titie compound. TLC, Rf (hexane/AcOEt 10/1) = 0.56. MS(EI+): 175 (M+1).
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Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2006/66896; (2006); A2;,
Bromide – Wikipedia,
bromide – Wiktionary