Application of 112734-22-2, These common heterocyclic compound, 112734-22-2, name is (4-Bromo-2-fluorophenyl)methanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Boc20 (106.96 mg, 490.10 muiotaetaomicron) and DMAP (5.99 mg, 49.01 muiotaetaomicron) were added to a solution of Compound BD2-2 (100.00 mg, 490.10 muiotaetaomicron) and TEA (148.78 mg, 1.47 mmol) in DCM (4.00 mL). The mixture was stirred at 15C for 12 hours. LCMS showed the reaction was completed. The mixture was concentrated to get crude residue. The residue was purified by prepatory-TLC (S1O2, Petroleum ether:Ethyl acetate mixture with a ratio of 5: 1) to afford Compound BD2-3 (90.00 mg, crude) as a yellow oil.
Statistics shows that (4-Bromo-2-fluorophenyl)methanamine is playing an increasingly important role. we look forward to future research findings about 112734-22-2.
Reference:
Patent; THE BROAD INSTITUTE, INC.; VACCA, Joseph, P.; (103 pag.)WO2018/75871; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary