Synthetic Route of 58971-11-2, A common heterocyclic compound, 58971-11-2, name is 3-Bromophenethylamine, molecular formula is C8H10BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 3-bromobenzeneethanamine (2.00 g, 10.0 mmol) and 2,6-lutidine (1.2 mL, 10.3 mmol) in dry CH2C12 (40 mL) was cooled to 0 C. Trifluoroacetic anhydride (1.4 mL, 9.9 mmol) was added dropwise, and the reaction was then warmed to room temperature and allowed to stir for 16 h. Water (40 mL) was added to the reaction, the phases were separated, and the aqueous layer was extracted with CHZCLZ (2 x 40 mL). The combined organic phases were washed successively with 1 M HCl (40 mL) and saturated NAHC03 (40 mL), and then dried over NazS04, filtered, and concentrated in vacuo to provide the title compound (2.93 g, 100%). The crude compound was used in subsequent steps. 1H-NMR (CDCl3): 8 7.40 (d, J=8. 0 Hz, 1H), 7.36 (s, 1H), 7.21 (t, J=7. 6 Hz, 1H), 7.12 (d, J=7. 6 Hz, 1H), 6.33 (br s, 1H), 3.59 (q, J=6. 8 Hz, 2H), 2.87 (t, J=7. 2 Hz, 2H). MS (ESI) (M+H) += 296/298.
The synthetic route of 58971-11-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; WO2004/60882; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary