Related Products of 24358-62-1, These common heterocyclic compound, 24358-62-1, name is 1-(4-Bromophenyl)ethylamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: (R)-1-(4-bromophenyl)ethanamine (2b) (2.00g, 10.0mmol) was dissolved in MeOH (50mL). To this solution was added 1-butanal (1.78mL, 20.0mmol) and NaBH(OAc)3 (4.24g, 20.0mmol). After stirring for 18h at room temperature, 5% NaOH was added. The mixture was extracted with CHCl3, dried over MgSO4, filtered, and concentrated under reduced pressure. The crude material was purified by silica gel column chromatography eluted with 5-10% MeOH in CHCl3 to afford the titled compound (2.17g, 85%) as a colorless oil. 1H NMR (400MHz, CDCl3) delta: 7.44 (d, J=8.8Hz, 2H), 7.19 (d, J=8.8Hz, 2H), 3.72 (q, J=6.8Hz, 1H), 2.50-2.44 (m, 1H), 2.41-2.34 (m, 1H), 1.47-1.38 (m, 2H), 1.35-1.24 (m, 5H), 0.87 (t, J=7.3Hz, 3H). 13C NMR (100MHz, CDCl3) delta: 143.5, 131.6(2C), 128.5(2C), 120.8, 57.9, 47.2, 31.7, 23.7, 20.3, 13.9. LC-MS (ESI) m/z=256 [M+H]+.
The synthetic route of 24358-62-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Imaizumi, Takamichi; Kobayashi, Atsuko; Otsubo, Shigeki; Komai, Masato; Magara, Megumiko; Otsubo, Nobumasa; Bioorganic and Medicinal Chemistry; vol. 27; 21; (2019);,
Bromide – Wikipedia,
bromide – Wiktionary