583-70-0, name is 2,4-Dimethylbromobenzene, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C8H9Br
To a suspension of Mg (1.32 g, 55 mmol) in THF (60 mL) was added a catalytic amount of and 1 -bromo-2,4-dimethylbenzene (0.50 g, 2.7 mmol). The reaction was initiated by heating and additional l-bromo-2,4-dimethylbenzene (8.75 g, 47.3 mmol) was added dropwise. The reaction mixture was stirred at rt for 4 h under N2. Benzonitrile (5.15 g, 50 mmol) was added dropwise to the Grignard system and the reaction mixture was stirred at rt for 16 h. The reaction was quenched by the addition of MeOH (20 mL), followed by portionwise addition of NaBH4 (1.9 g, 50 mmol). After stirring at rt for 5 h, the reaction was quenched by the addition of water (20 mL). Solvent was removed under reduced pressure. The residue was extracted with EtOAc (3 x 100 mL). The organic layer was washed with 1 N HC1 and the resultant precipitate was collected by filtration to afford the title compound (8.8 g, 84%) as a white solid. LC-MS-P1 : 195 [M- NH2]+; Rt: 1.232 min. lU NMR (500 MHz, DMSO-d6) delta ppm 9.15 (s, 2H), 7.55 (d, J= 8.0 Hz, IH), 7.45 – 7.32 (m, 5H), 7.12 (d, J= 8.0 Hz, IH), 7.04 (s, IH), 5.64 – 5.62 (m, IH), 2.27 (s, 3H), 2.22 (s, 3H).
The synthetic route of 583-70-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; BOHNERT, Gary, J.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; SUNG, Leonard; WO2013/19682; (2013); A1;,
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