In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 141474-37-5, name is 2,4-Dibromo-6-fluoroaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 2,4-Dibromo-6-fluoroaniline
General procedure: A mixture of 2-iodoaniline (0.20 mmol), phenyl isothiocyanate (0.22 mmol), DABCO (0.40 mmol, 2.0 equiv) and polystyrene-immobilized phenanthroline-Cu(I) catalyst 4 (20 mg, containing Cu 0.005 mmol) and toluene (1.0 mL) was stirred at 60 C for 8 h. After completion of the reaction as indicated by TLC, the mixture was cooled to room temperature and Et2O (5.0 mL) was added and the mixture stirred for 10 min to ensure product removal from catalyst. As supported catalyst 4 was precipitated to the bottom of the flask, the organic layer was decanted and the residue was washed with Et2O (2×5.0 mL). The combined organic layers were concentrated, and then the residue was purified by flash chromatography on silica gel to provide the corresponding pure product 7a in 95% yield.
The synthetic route of 141474-37-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Yang, Jin; Li, Pinhua; Wang, Lei; Tetrahedron; vol. 67; 31; (2011); p. 5543 – 5549;,
Bromide – Wikipedia,
bromide – Wiktionary