Reference of 626-88-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 626-88-0 as follows.
General procedure: 4-Bromomethylbiphenyl (402 mg, 1.63 mmol) and K2CO3(247 mg, 1.79 mmol) were added to a stirred solution of 237)(500 mg, 1.63 mmol) in DMF (5 mL), followed by stirring atroom temperature for 15 h. After the addition of water, themixture was extracted with AcOEt, washed with water andsaturated brine, and then dried over Na2SO4. The solventwas removed under reduced pressure. The residue obtainedwas purified by silica gel column chromatography to give 3j(790 mg, quant.) as a white solid.
According to the analysis of related databases, 626-88-0, the application of this compound in the production field has become more and more popular.
Reference:
Article; Morishita, Ko; Shoji, Yoshimichi; Fukui, Masaki; Ito, Yuma; Kitao, Tatsuya; Ozawa, Shin-ichiro; Hirono, Shuichi; Shirahase, Hiroaki; Chemical and Pharmaceutical Bulletin; vol. 66; 12; (2018); p. 1131 – 1152;,
Bromide – Wikipedia,
bromide – Wiktionary