Some common heterocyclic compound, 1074-24-4, name is 1,4-Dibromo-2,5-dimethylbenzene, molecular formula is C8H8Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 1074-24-4
1, 4-dibromo-2,5-dimethylbenzene: 1H-1,2,4-triazole: potassium carbonate: copper oxide molar ratio of 2: 10: 30: 1A solution of CuO (0.0398 mg, 0.5 mmol), potassium carbonate (2.0731 g, 15 mmol), 1H-1,2,4-triazole (0.345 g, 0.5 mmol), and triethylamine Mg, 5 mmol), 1,4-dibromo-2,5-dimethylbenzene (0.3360 g, 1 mmol), 20 mL of DMF. Stirring was started at 100oC for 24 hours. After the completion of the reaction, the reaction solution was cooled to room temperature, filtered, and the filtrate was added with 100 mL of water. A large amount of precipitate was precipitated, and the filter cake was collected by suction filtration at a yield of 60percent. Elemental analysis (C12N6H12) Calcd. (percent): C, 59.99; H, 5.03; N, 34.98. Found: C, 60.02; H, 5.05; N, 35.05;1,4-dibromo-2,5-dimethylbenzene 1H-1,2,4-triazole.In the present invention, the molar ratio of 1,4-dibromo-2,5-dimethylbenzene: 1H-1,2,4-triazole: potassium carbonate:2: 10: 30: 1; reaction temperature 80-200 , reaction time 12-120 hours. The organic compound was prepared by heating 1,4-dibromo-2,5-dimethylbenzene and 1H-1,2,4-triazole in a one-pot process. 1- (2,5- Dimethyl-4- (1H-1,2,4-Triazol-1-yl) phenyl) -1H-1,2,4-triazole (L).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1074-24-4, its application will become more common.
Reference:
Patent; Tianjin Normal University; Wang, Ying; (12 pag.)CN105418659; (2016); A;,
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