Reference of 10269-01-9,Some common heterocyclic compound, 10269-01-9, name is (3-Bromophenyl)methanamine, molecular formula is C7H8BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A suspension of 2,5-dihydroxybenzaldehye 1 (0.107g,1 mmol, 1equiv.) and MnO2 (0.860g, 10 mmol) in toluene, were cooledin ice bath to 0C under constant stirring for 15 min and amine (1 mmol, 1equiv.) was added. The mixture was refluxed for 10 h. The mixture was filtered through celite and washed withtoluene. Removal of the solvent under reduced pressure followed by columnchromatography (5% EtOAc/Hexane) yielded pure benzo[d]oxazole derivative.
The synthetic route of 10269-01-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Tangellamudi, Neelima D.; Shinde, Suchita B.; Pooladanda, Venkatesh; Godugu, Chandraiah; Balasubramanian, Sridhar; Bioorganic and Medicinal Chemistry Letters; vol. 28; 23-24; (2018); p. 3639 – 3647;,
Bromide – Wikipedia,
bromide – Wiktionary