Adding a certain compound to certain chemical reactions, such as: 348-57-2, name is 1-Bromo-2,4-difluorobenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 348-57-2, HPLC of Formula: C6H3BrF2
Step 1: Combine 2,4-difluorobromobenzene (6.00 g, 31 mmol) with AlCl3 (10.4 g, 34.3 mmol) and heat to 60° C. Add dropwise acetyl chloride (3.66 g, 47 mmol). Heat at 95° C. 1.5 h, cool to 0° C., and add ice-water, then conc. HCl (15 ml). Extract with ether, dry (MgSO4), concentrate and chromatograph on silica to obtain the ketone as a brown oil.
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Reference:
Patent; Neustadt, Bernard R.; Boyle, Craig D.; Chackalamannil, Samuel; Harris, Joel M.; Lankin, Claire M.; Liu, Hong; Shah, Unmesh; Stamford, Andrew; US2007/66620; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary