Synthetic Route of 13194-73-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13194-73-5, name is 3,5-Dibromo-4-methylaniline, This compound has unique chemical properties. The synthetic route is as follows.
Example 26 1,3-Dibromo-2-methylbenzene A solution of (3,5-dibromo-4-methylphenyl)amine dissolved in water (80 mL) and concentrated HCl (7.5 mL) stirring for 20 min, then the mixture was cooled to 0~5 C., and a solution of NaNO2 (3.4 g/40 mL H2O) was added. The reaction mixture was stirred for 2 h at 0~5 C., then the suspension was added to a solution of hypophosphorous acid (50%, 27.9 g), and the mixture was cooled to 0 C. The mixture was stirred at room temperature overnight. Then it was extracted with CH2Cl2 (100 mL*2). The organic layer was washed with brine (30 mL) and dried over Na2SO4. After silica column chomatography, (eluted with petroleum ether), 3.57 g product was obtained, as a colorless liquid. 1H NMR (400 MHz, CDCl3) delta 2.57 (s, 3H), 6.89 (t, J=8.0 Hz, 1H), 7.50 (d, J=8.0 Hz, 2H).
The chemical industry reduces the impact on the environment during synthesis 3,5-Dibromo-4-methylaniline. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Glaxo Group Limited; US2009/203657; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary