Electric Literature of 55289-36-6,Some common heterocyclic compound, 55289-36-6, name is 3-Bromo-2-methylaniline, molecular formula is C7H8BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Tetrakis(triphenylphosphine)palladium(0) (Aldrich, catNo.216666: 300 mg, 0.3 mmol) was added to a mixture of 3-bromo-2-methylaniline (Aldrich, catNo.530018: 1000 mg, 5 mmol), phenylboronic acid (Aldrich, catNo.P20009: 600 mg, 5 mmol), 1,4-dioxane (20 mL, 200 mmol) and water (3 mL, 200 mmol), and the mixture was allowed to stir at 100 C. overnight. After concentration, the residue was dissolved in DCM and washed with brine. The organic layer was dried and concentrated to afford desired product as a brown solid, which was used in the next step without further purification. LC-MS calculated for C13H14N (M+H)+: m/z=184.1; found 184.1.
The synthetic route of 55289-36-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Incyte Corporation; Yu, Zhiyong; Wu, Liangxing; Yao, Wenqing; (44 pag.)US2018/16260; (2018); A1;,
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