Reference of 58971-11-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 58971-11-2 as follows.
To a solution of 2-(3-bromophenyl)ethanamine (2 g, 10 mmol) in DCM (30 mL) were added Et3 (3 mL, 20.99 mmol) and AC2O (2 mL, 20.99 mmol). The reaction was stirred at rt overnight, then washed with H20 (50 mL x 3) followed by brine (50 mL x 3), dried over anhydrous a2S04, filtered and concentrated in vacuo to yield the crude product (2.42 g, 100%). MS (ESI, pos. ion) m/z: 242.0 [M + H]+; NMR (400 MHz, CDC13) delta (ppm): 7.36-7.33 (d, J= 9.2 Hz, 2H), 7.18-7.14 (t, J= 7.6 Hz, 1H), 7.12-7.10 (d, J= 8.0 Hz, 1H), 3.49-3.44 (t, J= 6.8 Hz, 2H), 2.79-2.76 (t, J= 7.2 Hz, 2H), 2.2 (s, 1H), 1.93 (s, 3H).
According to the analysis of related databases, 58971-11-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD; XI, Ning; WANG, Ruyong; WANG, Liang; WO2014/89324; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary