Adding a certain compound to certain chemical reactions, such as: 5153-40-2, name is 1-Bromo-2,3,4,5,6-pentamethylbenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5153-40-2, Recommanded Product: 1-Bromo-2,3,4,5,6-pentamethylbenzene
Nl ,N5-bis(2.3.4.5.6-pentamethylphenyOpentane- 1 ,5-diamine (Example 8) [0082] In a drybox, 2,3,4,5,6-pentamethylbromobenzene (750.0 mg, 3.30 mmol), 1,5-pentanediamine (195.2 muL, 1.67 mmol), sodium tertbutoxide (396.6 mg, 4.13 mmol), 3.0 mL of dimethyoxyethane, and 10.0 mM Pd(OAc)2 / CyPF-Z-Bu (82.5 muL, 8.25 x 10-4 mmol) were added to a 20 mL scintillation vial equipped with a magnetic stirbar and sealed with a cap containing a PTFE septum. The reaction was placed into a temperature controlled aluminum heating block and stirred at 100 0C for 6 h. After cooling to room temperature, the reaction mixture was partitioned between 100 mL H2O/Diethyle ether (Et20) (1 : 1), the organic phase separated and dried over MgSO4, followed by the removal of all volatiles to afford 619 mg (95.0 %) of the title compound.|0083) 1H NuMR spectra were obtained at 400 MHz and recorded relative to residual protio solvent. 13C NuMR spectra were obtained at 101 MHz and recorded relative to the residual solvent resonance. The spectra recorded are as follows: 1H NMR (CDC13, 400 MHz, 22 0C): delta 1.50-1.71(m, 6H), 2.21 (s, 6H), 2.22 (s, 12H), 2.25 (s, 12H), 2.84 (t, J = 12 Hz, 4H), 2.88 (br s, 2H). 13C NMR (CDC13, 101 MHz, 22 0C): delta 14.8, 16.5, 16.9, 25.0, 30.9, 49.9, 126.8, 129.6, 132.9, 143.7.
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Reference:
Patent; UNIVATION TECHNOLOGIES, LLC; JOHNS, Adam, M.; WO2010/53696; (2010); A2;,
Bromide – Wikipedia,
bromide – Wiktionary