Some common heterocyclic compound, 55289-36-6, name is 3-Bromo-2-methylaniline, molecular formula is C7H8BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C7H8BrN
A mixture of 1-bromo-2-methyl-3-aminobenzene 25.0 g, triphosgene 60.0 g and toluene 400 mL was stirred withheating under ref lux for three hours. The reaction mixtures after standing to cool were concentrated under reduced pressure to give l-bromo-3-isocyanato-2- methylbenzene 30.3 g.?H NMR (CDC13) : 2.42(3H, 5), 7.00(1H, dt, J=0.5, 8.0Hz), 7.05(1H, dd, J=1.7, 8.0Hz), 7.39(1H,dd, 1.5, 7.7Hz).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 55289-36-6, its application will become more common.
Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; YOSHIMOTO, Yuya; TAKAHASHI, Teruki; OOHIRA, Daisuke; AZUMA, Shuhei; WO2013/162077; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary