Reference of 6274-57-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6274-57-3 as follows.
a.; A solution of (4-bromobenzyl)dimethylarnine (120 g, 0.50 mole) in THF (2 L) was cooled to -78 0C and treated dropwise with n-BuLi (47 g, 0.728 mole). The reaction mixture was stirred for 1 hour and then butyl borate (194 g, 0.84 mole) was added dropwise. The reaction mixture was stirred for 1 hour, allowed to warm to 0 0C, and then quenched by the addition of water (1.5 L). The reaction mixture was washed with ether (2 x 1 L), and the aqueous layer taken on to the next step.
According to the analysis of related databases, 6274-57-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2007/18941; (2007); A2;,
Bromide – Wikipedia,
bromide – Wiktionary