Application of 67567-26-4, A common heterocyclic compound, 67567-26-4, name is 4-Bromo-2,6-difluoroaniline, molecular formula is C6H4BrF2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
4-Bromo-2,6-difluoroaniline (5.00 g, 24.0 mmol, 1.00 equiv) and copper(I) cyanide (6.45 g, 72.0 mmol, 3.00 equiv) were suspended in 50 mL DMF and heated at 120 C for 24 h. After cooling to room temperature, the mixture was poured into an aqueous solution of ammonia (12%, v%, 250 mL). The mixture was then filtered and the precipitate was washed with EtOAc (500 mL). The organic phases were combined and washed with the ammonia solution (500 mL), distilled water (500 mL), brine (500 mL) and dried over anhydrous MgSO4. Solvents were removed under reduced pressure. The crude was purified by flash column chromatography (CH2Cl2/n-pentane, 2:1, v/v) to yield the desired compound (1.88 g, 12.2 mmol, 51%) as a white solid.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Zhang, Lei; Linden, Greta; Vazquez, Olalla; Beilstein Journal of Organic Chemistry; vol. 15; (2019); p. 2500 – 2508;,
Bromide – Wikipedia,
bromide – Wiktionary